My functional genomics journal watch - year 2000 [ this week | 2004 Jul-Dec | 2004 Jan-Jun | 2003 Jul-Dec | 2003 Jan-Jun | 2002 | 2001 | 2000 | 1999 | 1998 ]

General
Nature Insight: Functional genomics 2000 Jun 15 (405)
Genome
    Arabidopsis thaliana
    Drosophila melanogaster/ fruitfly
    Homo Sapien/ Human
    Pseudomonas aeruginosa
    Vibrio cholerae
Applications
Pharmacogenomics
Techniques & Tools
Ethical, Legal and Social issues		 Can't find the functional genomics article published in 2000 in my site? 
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General

  1. Aldhous P. Genomics. Beyond the book of life. Nature. 2000 Dec 21-28;408(6815):894-6. [PubMed][pdf]
  2. Smaglik P. Forces for collaboration falter with human genome in sight. Nature 2000 Dec 14; 408:758 [PubMed][pdf]
  3. Smaglik P. Faster sequencing slows down release of mouse gene data. Nature 2000 Dec 14; 408:758 [PubMed][pdf]
  4. Broder S, Venter JC. Whole genomes: the foundation of new biology and medicine. Curr Opin Biotechnol. 2000 Dec 1;11(6):581-585. [PubMed]
  5. Cockett M, Dracopoli N, Sigal E. Applied genomics: integration of the technology within pharmaceutical research and development. Curr Opin Biotechnol. 2000 Dec 1;11(6):602-609. [PubMed]
  6. Lawn RM, Lasky LA. Pharmaceutical biotechnology. The genomes are just the beginning. Curr Opin Biotechnol. 2000 Dec 1;11(6):579-580. [PubMed]
  7. Mayer ML, Hieter P. Protein networks-built by association. Nat Biotechnol. 2000 Dec;18(12):1242-1243. [PubMed]
  8. Butler D. Wellcome Trust funds bid to unravel zebrafish genome. Nature 2000. Nov 30; 408: 503-504 [PubMed]
  9. Abbott A. Europe boosts genome resource centres...as German genomics gets cash windfall. Nature. 2000 Nov 23;408(6811):393. [PubMed][pdf]
  10. Gerlt JA, Babbitt. Can sequence determine function? Review. Genome Biology 2000; 1;5:0005.1-0005.10 [pdf]
  11. Disotell TR. Human genomic variation. Genome Biology 2000; 1;5:2004.1-2004.2 [pdf]
  12. Cyranoski D. Singapore to create nationwide disease database. Nature. 2000 Oct 26;407(6807):935. [PubMed][pdf]
  13. Smaglik P. Leroy Hood. For my next trick...Is it possible to produce a complete mathematical description of complex biological systems? Nature. 2000 Oct 19;407(6806):828-9. [PubMed][pdf]
  14. Adam D. UK to make the northwest a post-genomics hotspot. Nature. 2000 Oct 19; 407:822 [pdf]
  15. Smaglik P, Abbott A. Project offers free mouse sequence. Nature. 2000 Oct 12;407(6805):663-4. [PubMed][pdf]
  16. Dunham I. Genomics - the new rock and roll? Trends Genet. 2000 Oct;16(10):456-461. [PubMed]
  17. Eisenberg RS. Genomics in the public domain: strategy and policy. Nature reviews genetics. 2000 Oct; 1:70-74.
  18. Milking the genome for profit. Nat Biotechnol. 2000 Oct;18(10):1045-1048. [PubMed]
  19. Altshuler D, Daly M, Kruglyak L. Guilt by association. Nat Genet. 2000 Oct;26(2):135-137. [PubMed]
  20. Andersson SGE. The genomics gamble. Nat Genet. 2000 Oct;26(2):134-140.
  21. Snyder M. A new journal for the post-genome era. Funct Integr Genomics. 2000 1:1 [link to journal]
  22. Bentley DR. Decoding the human genome sequence. Hum Mol Genet. 2000 Oct 12;9(16):2353-2358. [PubMed]
  23. Gerlai RT. Genotype x environment interaction: an old problem in a new field. Trends Neurosci. 2000 Oct 1;23(10):450. [PubMed]
  24. Cowan D. Genomics: Use your neighbour's genes. Nature. 2000 Sep 28; 407: 466-467. [PubMed]
  25. Cyranoski D. Japan opens access to mouse cDNA data...and to report on strengths and weaknesses of genomics centre. Nature. 2000 Sep 21;407(6802):279. [PubMed][pdf]
  26. Goffeau A. Four years of post-genomic life with 6000 yeast genes.  FEBS Lett. 2000 Aug 25;480(1):37-41. [PubMed]
  27. Fraser CM, Eisen JA, Salzberg SL. Microbial genome sequencing. Nature. 2000 Aug 17;406(6797):799-803. [PubMed]
  28. Denny P, Justice MJ. Mouse as the measure of man? Trends Genet. 2000 Jul;16(7):283-7. Review. [PubMed]
  29. Macilwain C. World leaders heap praise on human genome landmark. Nature. 2000 Jun 29;405(6790):983-4. [PubMed][pdf]
  30. Vukmirovic OG, Tilghman SM. Exploring genome space. Nature. 2000 Jun 15;405(6788):820-2. Review. [PubMed]
  31. Butler D, Smaglik P. Draft data leave geneticists with a mountain still to climb. Nature. 2000 Jun 29;405(6790):984-5. [PubMed][pdf]
  32. Loder N. Gene bank to offer family album of mammals. Nature. 2000 May 18;405(6784):265. [PubMed][pdf]

Nature Insight: Functional genomics 2000 Jun 15 (405)

  1. Vukmirovic OG, Tilghman SM. Exploring genome space. Nature. 2000 Jun 15;405(6788):820-2. Review. [PubMed]
  2. Eisenberg D, Marcotte EM, Xenarios I, Yeates TO. Protein function in the post-genomic era.  Nature. 2000 Jun 15;405(6788):823-6. Review. [PubMed]
  3. Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays.  Nature. 2000 Jun 15;405(6788):827-36. Review. [PubMed]
  4. Pandey A, Mann M. Proteomics to study genes and genomes. Nature. 2000 Jun 15;405(6788):837-46. Review. [PubMed]
  5. Risch NJ. Searching for genetic determinants in the new millennium. Nature. 2000 Jun 15;405(6788):847-56. Review. [PubMed]
  6. Roses AD. Pharmacogenetics and the practice of medicine.  Nature. 2000 Jun 15;405(6788):857-65. Review. [PubMed]

Genome

  1. Celniker SE. The Drosophila genome. Curr Opin Genet Dev. 2000 Dec 1;10(6):612-616. [PubMed]
  2. Johnston M. The yeast genome: on the road to the Golden Age. Curr Opin Genet Dev. 2000 Dec 1;10(6):617-623. [PubMed]
  3. Cyranoski D, Smaglik P. Puffer fish joins genome stampede. Nature 2000. Nov 2; 6-7 [PubMed][pdf]
  4. Wiehe T, Guigo R, Miller W. Genome sequence comparisons: hurdles in the fast lane to functional genomics. Brief Bioinform. 2000 Nov;1(4):381-8. [PubMed]
  5. Nelson KE, Paulsen IT, Heidelberg JF, Fraser CM. Status of genome projects for nonpathogenic bacteria and archaea. Nat Biotechnol. 2000 Oct;18(10):1049-1054. [PubMed]
  6. Rison SCG, Hodgman TC, Thornton JM. Comparison of functional annotation schemes for genomes. Funct Integr Genomics. 2000 1:1 [link to journal]
  7. Martienssen RA. Weeding out the genes: the Arabidopsis genome project. Funct Integr Genomics. 2000 1:2-11 [link to journal]
  8. Ostrander EA, Kruglyak L. Unleashing the Canine Genome. Genome Res. 2000 Sep;10(9):1271-1274. [PubMed]
  9. Varki A. A Chimpanzee Genome Project Is a Biomedical Imperative. Genome Res. 2000 Aug;10(8):1065-1070. [PubMed]
  10. Triendl R.  Study compares chimps and people. Nature. 2000 Jul 6;406(6791):4. [PubMed][pdf]
  11. Smaglik P.  Genetic diversity project fights for its life...as companies are urged to share benefits.  Nature. 2000 Apr 27;404(6781):912. [PubMed][pdf]
  12. Loder N. Celera's shotgun approach puts Drosophila in the bag. Nature. 2000 Feb 24;403(6772):817. [PubMed]
  13. Smaglik P, Butler D. Celera turns to public genome data to speed up endgame. Nature. 2000 Jan 13;403(6766):119. [PubMed]

Arabidopsis thaliana

  1. Dennis C, Surridge C. A. thaliana genome. Nature 2000 Dec 14; 408, 791 [pdf]
  2. Adam D. A. thaliana genome. Now for the hard ones. Nature 2000 Dec 14; 408, 792-793 [PubMed][pdf]
  3. Walbot V. A. thaliana genome. A green chapter in the book of life. Nature 2000 Dec 14; 408, 794-795 [PubMed][pdf]
  4. The Arabidopsis Genome Initiative. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 2000 Dec 14; 796-815 [PubMed][pdf]
  5. THEOLOGIS, A., ECKER, J.R. et al. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Nature 2000 Dec 14; 816-820 [PubMed][pdf]
  6. EUROPEAN UNION CHROMOSOME 3 ARABIDOPSIS SEQUENCING CONSORTIUM, THE INSTITUTE FOR GENOMICS RESEARCH & KAZUSA RESEARCH INSTITUTE. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature 2000 Dec 14; 820-823 [PubMed][pdf]
  7. THE KAZUSA DNA RESEARCH INSTITUTE, THE COLD SPRING HARBOR AND WASHINGTON UNIVERSITY IN ST LOUIS SEQUENCING CONSORTIUM & THE EUROPEAN UNION ARABIDOPSIS GENOME SEQUENCING CONSORTIUM. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature 2000 Dec 14; 823-826 [PubMed][pdf]

Drosophila melanogaster/ fruitfly

  1. Adams MD et al. The genome sequence of Drosophila melanogaster. Science. 2000 Mar 24;287(5461):2185-95. [PubMed]
  2. Myers EW et al. A whole-genome assembly of Drosophila. Science. 2000 Mar 24;287(5461):2196-204. [PubMed]
  3. Rubin GM et al. Comparative genomics of the eukaryotes.  Science. 2000 Mar 24;287(5461):2204-15. [PubMed]

Homo Sapien/ Human

  1. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Soeda E, Ohki M, Takagi T, Sakaki Y,  Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A.  The DNA sequence of human chromosome 21. The chromosome 21 mapping and sequencing consortium.  Nature. 2000 May 18;405(6784):311-9. [PubMed][pdf]

Pseudomonas aeruginosa

  1. Nouwens AS, Cordwell SJ, Larsen MR, Molloy MP, Gillings M, Willcox MD, Walsh BJ.  Complementing genomics with proteomics: the membrane subproteome of Pseudomonas aeruginosa PAO1.  Electrophoresis. 2000 Nov;21(17):3797-809. [PubMed]
  2. Greenberg EP. Bacterial genomics: Pump up the versatility. Nature. 2000 Aug 21; 406(6799): 947-948 [PubMed]
  3. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z,  Paulsen IT.  Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen.  Nature. 2000 Aug 31;406(6799):959-64. [PubMed][pdf]

Vibrio cholerae

  1. Waldor MK, RayChaudhuri D. Treasure trove for cholera research.  Nature. 2000 Aug 3;406(6795):469-70. [PubMed][pdf]
  2. Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O.  DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.  Nature. 2000 Aug 3;406(6795):477-83. [PubMed][pdf]

Applications

  1. Matoba R, Saito S, Ueno N, Maruyama C, Matsubara K, Kato K. Gene expression profiling of mouse postnatal cerebellar development. Physiol Genomics. 2000 Dec 18;4(2):155-164. [PubMed]
  2. Lawrence RN. Key strategies in functional genomics for drug discovery. Drug Discov Today. 2000 Dec 1;5(12):536-538. [PubMed]
  3. Loferer H. Mining bacterial genomes for antimicrobial targets. Mol Med Today. 2000 Dec 1;6(12):470-474. [PubMed]
  4. Eisen JA. Horizontal gene transfer among microbial genomes: new insights from complete genome analysis. Curr Opin Genet Dev. 2000 Dec 1;10(6):606-611. [PubMed]
  5. Schwikowski B, Uetz P, Fields S. A network of protein-protein interactions in yeast. Nat Biotechnol. 2000 Dec;18(12):1257-1261. [PubMed][Web]
  6. Aguan K, Carvajal JA, Thompson LP, Weiner CP. Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour. Mol Hum Reprod. 2000 Dec;6(12):1141-1145. [PubMed]
  7. Kaplan JC, Junien C.  Genomics and medicine: an anticipation. From Boolean Mendelian genetics to multifactorial molecular medicine.  C R Acad Sci III. 2000 Dec;323(12):1167-74. [PubMed]
  8. Goh SH, Park JH, Lee YJ, Lee HG, Yoo HS, Lee IC, Park JH, Kim YS, Lee CC. Gene Expression Profile and Identification of Differentially Expressed Transcripts during Human Intrathymic T-Cell Development by cDNA Sequencing Analysis. Genomics. 2000 Nov 15;70(1):1-18.
  9. Fraser AG, Kamath RS, Zipperien P, Martinez-Campos M, Sohrmann M, Ahringer J. Functional genomic analysis of C.elegans chromosome I by systematic RNA interference. Nature. 2000 Nov 16; 408; 325- 330 [link to journal]
  10. PIERRE GÖNCZY, CHRISTOPHE ECHEVERRI, KAREN OEGEMA, ALAN COULSON, STEVEN J. M. JONES, RICHARD R. COPLEY, JOHN DUPERON, JEFF OEGEMA, MICHAEL BREHM, ETIENNE CASSIN, EVA HANNAK, MATTHEW KIRKHAM, SILKE PICHLER, KATHRIN FLOHRS, ANOESJKA GOESSEN, SEBASTIAN LEIDEL, ANNE-MARIE ALLEAUME, CÉCILIE MARTIN, NURHAN ÖZLÜ, PEER BORK & ANTHONY A. HYMAN. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III .  Nature. 2000 Nov 16; 408; 331- 336 [link to journal]
  11. Manson McGuire A, Church GM. Predicting regulons and their cis-regulatory motifs by comparative genomics. Nucleic Acids Res. 2000 Nov 15;28(22):4523-30. [PubMed]
  12. Long M. A New Function Evolved from Gene Fusion.  Genome Res. 2000 Nov;10(11):1655-1657. [PubMed]
  13. Kawamoto S, Yoshii J, Mizuno K, Ito K, Miyamoto Y, Ohnishi T, Matoba R, Hori N, Matsumoto Y, Okumura T, Nakao Y, Yoshii H, Arimoto J, Ohashi H, Nakanishi H, Ohno I, Hashimoto J, Shimizu K, Maeda K, Kuriyama H, Nishida K, Shimizu-Matsumoto A, Adachi W, Ito R, Kawasaki S, Chae KS, Murakawa K, Yokoyama M, Fukushima A, Hishiki T, Nakaya A, Sese J, Monma N, Nikaido H, Morishita S, Matsubara K, Okubo K. BodyMap: A Collection of 3' ESTs for Analysis of Human Gene Expression Information. Genome Res. 2000 Nov;10(11):1817-1827. [PubMed]
  14. de Souza SJ, Camargo AA, Briones MR, Costa FF, Nagai MA, Verjovski-Almeida S, Zago MA, Andrade LE, Carrer H, El-Dorry HF, Espreafico EM, Habr-Gama A, Giannella-Neto D, Goldman GH, Gruber A, Hackel C, Kimura ET, Maciel RM, Marie SK, Martins EA, Nobrega MP, Paco-Larson ML, Pardini MI, Pereira GG, Pesquero JB, Rodrigues V, Rogatto  SR, da Silva ID, Sogayar MC, de Fatima Sonati M, Tajara EH, Valentini SR, Acencio M, Alberto FL, Amaral ME,  Aneas I, Bengtson MH, Carraro DM, Carvalho AF, Carvalho LH, Cerutti JM, Correa ML, Costa MC, Curcio C, Gushiken T, Ho PL, Kimura E, Leite LC, Maia G, Majumder P, Marins M, Matsukuma A, Melo AS, Mestriner CA, Miracca EC, Miranda DC, Nascimento AL, Nobrega FG, Ojopi EP, Pandolfi JR, Pessoa LG, Rahal P, Rainho CA, da  Ro's N, de Sa RG, Sales MM, da Silva NP, Silva TC, da Silva W Jr, Simao DF, Sousa JF, Stecconi D, Tsukumo F, Valente V, Zalcberg H, Brentani RR, Reis LF, Dias-Neto E, Simpson AJ. Identification of human chromosome 22 transcribed sequences with ORF expressed sequence tags. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12690-12693. [PubMed][pdf]
  15. Sun YH, Bakshi S, Chalmers R, Tang CM. Functional genomics of Neisseria meningitidis pathogenesis. Nat Med. 2000 Nov;6(11):1269-1273. [PubMed]
  16. Fiehn O, Kopka J, Dormann P, Altmann T, Trethewey RN, Willmitzer L. Metabolite profiling for plant functional genomics. Nat Biotechnol. 2000 Nov;18(11):1157-1161. [PubMed]
  17. Chakravarti DN, Fiske MJ, Fletcher LD, Zagursky RJ. Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates. Vaccine. 2000 Nov 8;19(6):601-12. [PubMed]
  18. Hill AA, Hunter CP, Tsung BT, Tucker-Kellogg G, Brown EL. Genomic analysis of gene expression in C. elegans. Science 2000. Oct 27; 290:809-812
  19. Bain G, Mansergh FC, Wride MA, Hance JE, Isogawa A, Rancourt SL, Ray WJ, Yoshimura Y, Tsuzuki T, Gottlieb DI, Rancourt DE. ES cell neural differentiation reveals a substantial number of novel ESTs. Funct Integr Genomics. 2000 1:127-139
  20. Ross-Macdonald P. Functional analysis of the yeast genome. Funct Integr Genomics. 2000 1:99-113
  21. Sleeman MA, Murison JG, Strachan L, Kumble K, Glenn MP, McGrath A, Grierson A, Havukkala I, Tan PL, Watson JD. Gene Expression in Rat Dermal Papilla Cells: Analysis of 2529 ESTs. Genomics. 2000 Oct 15;69(2):214-224. [PubMed]
  22. Drawid A, Jansen R, Gerstein M. Genome-wide analysis relating expression level with protein subcellular localization.Trends Genet. 2000 Oct;16(10):426-430. [PubMed]
  23. Wasserman WW, Palumbo M, Thompson W, Fickett JW, Lawrence CE. Human-mouse genome comparisons to locate regulatory sites. Nat Genet. 2000 Oct;26(2):225-228. [PubMed]
  24. Tsoka S, Ouzounis CA. Prediction of protein interactions: metabolic enzymes are frequently involved in gene fusion. Nat Genet. 2000 Oct;26(2):141-142. [PubMed]
  25. Das R, Gerstein M. The stability of thermophilic proteins: a study based on comprehensive genome comparison. Funct Integr Genomics. 2000 1:1 [link to journal]
  26. Palmer LJ, Cookson WO. Genomic Approaches to Understanding Asthma. Genome Res. 2000 Sep;10(9):1280-1287. [PubMed]
  27. Chien KR. Genome circuits and the integrative biology of cardiac diseases. Nature 2000 Sep; 407: 227-232 [link to journal]
  28. Rubin EM, Tall A. Perspectives for vascular genomics. Nature 2000 Sep; 407:265-269 [link to journal]
  29. Montgomery DL. Tuberculosis vaccine design: influence of the completed genome sequence.  Brief Bioinform. 2000 Sep;1(3):289-96. [PubMed]
  30. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Genes expressed in human tumor endothelium. Science. 2000 Aug 18;289(5482):1197-202. [PubMed]
  31. Venkatesh B, Gilligan P, Brenner S. Fugu: a compact vertebrate reference genome. FEBS Lett. 2000 Jun 30;476(1-2):3-7. Review. [PubMed]
  32. Rubin GM et al. Comparative genomics of the eukaryotes.  Science. 2000 Mar 24;287(5461):2204-15. [PubMed]
  33. Kohro T, Nakajima T, Wada Y, Sugiyama A, Ishii M, Tsutsumi S, Aburatani H, Imoto I, Inazawa J, Hamakubo T, Kodama T, Emi M.  Genomic structure and mapping of human orphan receptor LXR alpha: upregulation of LXRa mRNA during monocyte to macrophage differentiation.  J Atheroscler Thromb. 2000;7(3):145-51. [PubMed]

Pharmacogenomics

  1. Michelson S, Joho K.  Drug discovery, drug development and the emerging world of pharmacogenomics: prospecting for information in a data-rich landscape.  Curr Opin Mol Ther. 2000 Dec;2(6):651-4. [PubMed]
  2. Kawanishi Y, Tachikawa H, Suzuki T.   Pharmacogenomics and schizophrenia.  Eur J Pharmacol. 2000 Dec 27;410(2-3):227-241. [PubMed]
  3. Davidson S. Research suggests importance of haplotypes over SNPs. Nat Biotechnol. 2000 Nov;18(11):1134-1135. [PubMed]
  4. Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K, Arnold K, Ruano G, Liggett SB. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and  predict in vivo responsiveness.  Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10483-8. [PubMed][pdf]
  5. Samani NJ.  Pharmacogenomics of hypertension: a realizable goal? Clin Sci (Colch). 2000 Sep 1;99(3):231-232. [PubMed]
  6. Furness LM, Henrichwark S, Egerton M.  Expression databases--resources for pharmacogenomic R&D.  Pharmacogenomics. 2000 Aug;1(3):281-8. [PubMed]
  7. Jain KK.  Applications of biochip and microarray systems in pharmacogenomics.  Pharmacogenomics. 2000 Aug;1(3):289-307. [PubMed]
  8. Cunningham MJ.  Genomics and proteomics. The new millennium of drug discovery and development.  J Pharmacol Toxicol Methods. 2000 Jul;44(1):291-300. [PubMed]
  9. Schweighoffer F, Ait-Ikhlef A, Resink AL, Brinkman B, Melle-Milovanovic D, Laurent-Puig P, Kearsey J, Bracco L.  Qualitative gene profiling: a novel tool in genomics and in pharmacogenomics that deciphers messenger RNA isoforms diversity.  Pharmacogenomics. 2000 May;1(2):187-97. [PubMed]
  10. Saundersa AM, Trowersb MK, Shimketsc RA, Blakemoreb S, Crowtherb DJ, Mansfieldc TA, Wallaceb DM, Strittmattera WJ, Rosesd AD. The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochim Biophys Acta. 2000 Jul 26;1502(1):85-94. [PubMed]
  11. Woolley AT, Guillemette C, Li Cheung C, Housman DE, Lieber CM. Direct haplotyping of kilobase-size DNA using carbon nanotube probes. Nat Biotechnol. 2000 Jul;18(7):760-3. [PubMed]
  12. Taton TA, Mirkin CA. Haplotyping by force.  Nat Biotechnol. 2000 Jul;18(7):713. [PubMed]
  13. Roses AD. Pharmacogenetics and the practice of medicine.  Nature. 2000 Jun 15;405(6788):857-65. Review. [PubMed]
  14. March R. Pharmacogenomics: the genomics of drug response. Yeast. 2000 Apr;17(1):16-21. Review. [PubMed]

Techniques & Tools

  1. Goh SH, Park JH, Lee YJ, Lee HG, Yoo HS, Lee IC, Park JH, Kim YS, Lee CC. Gene Expression Profile and Identification of Differentially Expressed Transcripts during Human Intrathymic T-Cell Development by cDNA Sequencing Analysis. Genomics. 2000 Nov 15;70(1):1-18. [PubMed]
  2. Kawamoto S, Yoshii J, Mizuno K, Ito K, Miyamoto Y, Ohnishi T, Matoba R, Hori N, Matsumoto Y, Okumura T, Nakao Y, Yoshii H, Arimoto J, Ohashi H, Nakanishi H, Ohno I, Hashimoto J, Shimizu K, Maeda K, Kuriyama H, Nishida K, Shimizu-Matsumoto A, Adachi W, Ito R, Kawasaki S, Chae KS, Murakawa K, Yokoyama M, Fukushima A, Hishiki T, Nakaya A, Sese J, Monma N, Nikaido H, Morishita S, Matsubara K, Okubo K. BodyMap: A Collection of 3' ESTs for Analysis of Human Gene Expression Information. Genome Res. 2000 Nov;10(11):1817-1827. [PubMed]
  3. Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y, Izawa M, Ohara E, Watahiki M, Yoneda Y, Ishikawa T, Ozawa K, Tanaka T, Matsuura S, Kawai J, Okazaki Y, Muramatsu M, Inoue Y, Kira A, Hayashizaki Y. RIKEN Integrated Sequence Analysis (RISA) System-384-Format Sequencing Pipeline with 384 Multicapillary Sequencer. Genome Res. 2000 Nov;10(11):1757-1771. [PubMed]
  4. Harris S, Foord SM. Transgenic gene knock-outs: functional genomics and therapeutic target selection.  Pharmacogenomics. 2000 Nov;1(4):433-43. [PubMed]
  5. Wasserman WW, Palumbo M, Thompson W, Fickett JW, Lawrence CE. Human-mouse genome comparisons to locate regulatory sites. Nat Genet. 2000 Oct;26(2):225-228. [PubMed]
  6. Cohen BA, Mitra RD, Hughes JD, Church GM. A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression. Nat Genet. 2000 Oct;26(2):183-186. [PubMed]
  7. Gray IC, Campbell DA, Spurr NK. Single nucleotide polymorphisms as tools in human genetics. Hum Mol Genet. 2000 Oct 12;9(16):2403-2408. [PubMed]
  8. Mullikin JC et.al. An SNP map of human chromosome 22. Nature. 2000 Sep 28; 407:516-520. [link to journal]
  9. Altshuler D. An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature. 2000 Sep 28; 407: 513-516. [link to journal]
  10. Z Yang, G Ka-Shu Wong, M A Eberle, M Kibukawa, D A Passey, W R Hughes, L Kruglyak & J Yu. Sampling SNPs. Nature Genet. 2000 Sep 1;26 (1):13 - 14 [link to journal]
  11. Ewen KR, Bahlo M, Treloar SA, Levinson DF, Mowry B, Barlow JW, Foote SJ. Identification and Analysis of Error Types in High-Throughput Genotyping. Am J Hum Genet. 2000 Sep;67(3):727-736. [PubMed]
  12. Meldrum D. Automation for Genomics, Part One: Preparation for Sequencing. Genome Res. 2000 Aug;10(8):1081-1092. [PubMed]
  13. Stollberg J, Urschitz J, Urban Z, Boyd CD. A Quantitative Evaluation of SAGE. Genome Res. 2000 Aug;10(8):1241-1248. [PubMed]
  14. Alderborn A, Kristofferson A, Hammerling U.  Determination of single-nucleotide polymorphisms by real-time pyrophosphate DNA sequencing.  Genome Res. 2000 Aug;10(8):1249-58. [PubMed]
  15. Cecconi F, Meyer BI. Gene trap: a way to identify novel genes and unravel their biological function. FEBS Lett. 2000 Aug 25;480(1):63-71. [PubMed]
  16. Abbott A. A mutant mouse menagerie. Nature. 2000 Aug 10;406(6796):559. No abstract available. [PubMed]
  17. Nolan PM, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray IC, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K,Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, StevensonJA, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel KP, Voegeling S, Guenet JL, NickolsC, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher EM, Martin J, Rastan S, Brown SD, Hunter J. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet. 2000 Aug;25(4):440-3. [PubMed]
  18. Hrabe de Angelis MH, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S,Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7. [PubMed]
  19. Nolan PM.  Generation of mouse mutants as a tool for functional genomics. Pharmacogenomics. 2000 Aug;1(3):243-55. [PubMed]
  20. Coelho PS, Kumar A, Snyder M.  Genome-wide mutant collections: toolboxes for functional genomics.  Curr Opin Microbiol. 2000 Jun;3(3):309-15. Review. [PubMed]

Ethical, Legal and Social issues

  1. Smaglik P. Publication deal for celera sparks row over data access. Nature. 2000 Dec 14;408(6814):759 [PubMed][pdf]
  2. Gold ER. Moving the gene patent debate forward. Nat Biotechnol. 2000 Dec;18(12):1319-1320. [PubMed]
  3. Niiler E. Company, academics argue over data. Nat Biotechnol. 2000 Dec;18(12):1235. [PubMed]
  4. Hodgson j. First Genetic Trust banks on genes. Nat Biotechnol. 2000 Dec; 18(12):1236 [PubMed]
  5. Gannon F. The discovery of functional genomics - EU announces new funding approach for European research. EMBO Reports 2000. 1(5); 386-387
  6. Gene-therapy death prompts broad civil lawsuit. Nat Biotechnol. 2000 Nov;18(11):1136. [PubMed]
  7. Smaglik P. Tissue donors use their influence in deal over gene patent terms. Nature. 2000 Oct 19:407: 821
  8. Keilbart M. Social responsibility in human genetics - a survey. Funct Integr Genomics. 2000 1: 150-151
  9. Eisenberg RS. Genomics in the public domain: strategy and policy. Nat Rev Genet. 2000 Oct 1:70-74
  10. Biotech exec jailed. Nat Biotechnol. 2000 Oct;18(10):1024. [PubMed]
  11. Triendl R. Japan seeks to unify ethics rules on genomics research.  Nature. 2000 Aug 17;406(6797):665. [PubMed][pdf]
  12. Macilwain C. World leaders heap praise on human genome landmark. Nature. 2000 Jun 29;405(6790):983-4. [PubMed][pdf]
  13. Smaglik P. Relations thaw between genome rivals as finish line draws near. Nature. 2000 Jun 15;405(6788):721. [PubMed][pdf]
  14. Debates over credit for the annotation of genomes. Nature. 2000 Jun 15;  405: 721[pdf]
  15. Macilwain C. Biologists challenge sequencers on parasite genome publication. Nature. 2000 Jun 8;405(6787):601-2. [PubMed][pdf]
  16. Abbott A. Drive for more genomes threatens mouse sequence. Nature. 2000 Jun 8;405(6787):602-3. [PubMed][pdf]
  17. Triendl R. Japan calls for open access to human genome data. Nature. 2000 May 18;405(6784):265. [PubMed][pdf]
  18. Avoid wacky (genome) races. Nature. 2000 May 11;405(6783):103. [PubMed]
  19. Smaglik P. Critics challenge Celera's claims over human genome sequence...as biotech debate splits along party lines. Nature. 2000 Apr 13;404(6779):691-2. [PubMed]
  20. Butler D. US/UK statement on genome data prompts debate on 'free access'. Nature. 2000 Mar 23;404(6776):324-5.  [PubMed]
  21. Rules of genome access. Nature. 2000 Mar 23;404(6776):317. [PubMed]
  22. Loder N. Rival demands sink genome alliance plans. Nature. 2000 Mar 9;404(6774):117. [PubMed]
  23. Private vs public genomics? Nature. 2000 Jan 13;403(6766):117. [PubMed]
  24. Butler D, Smaglik P. Celera genome licensing terms spark concerns over 'monopoly'. Nature. 2000 Jan 20;403(6767):231. [PubMed]

last updated: 21 Oct 2001
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