My functional genomics journal watch - year 2004 Jan-Jun [ this week | 2004 Jul-Dec | 2004 Jan-Jun | 2003 Jul-Dec | 2003 Jan-Jun | 2002 | 2001 | 2000 | 1999 | 1998 ]

General
Genome
   Homo Sapiens/Human
   Mus Musculus/Mouse
   Rattus norvegicus/Rat
   Rhodopseudomonas palustris
Comparative Genomics
Population Genomics/Evolutionary Genomics
Network/pathway reconstruction and analysis
Metabolomics
Pharmacogenomics
Toxicogenomics
System Biology
Database
Applications
Single Nucleotide Polymorphisms (SNPs) & haplotyping (typing, validation and mapping)
Techniques & Tools
Ethical, Legal and Social issues		 Can't find the functional genomics article published in 2003 in my site? 
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General

  1. Fraser AG, Marcotte EM. A probabilistic view of gene function. Nat Genet. 2004 Jun;36(6):559-64. [PubMed]
  2. Altshuler JS, Altshuler D. Organizational challenges in clinical genomic research. Nature. 2004 May 27;429(6990):478-81. [PubMed]
  3. Robinson GE. Genomics. Beyond nature and nurture. Science. 2004 Apr 16;304(5669):397-9. [PubMed]
  4. Steinmetz LM, Davis RW. Maximizing the potential of functional genomics. Nat Rev Genet. 2004 Mar;5(3):190-201. [PubMed]
  5. Qiang B. Human genome research in China. J Mol Med. 2004 Feb 27 [Epub ahead of print] [PubMed]
  6. King RD, Whelan KE, Jones FM, Reiser PG, Bryant CH, Muggleton SH, Kell DB, Oliver SG. Functional genomic hypothesis generation and experimentation by a robot scientist. Nature. 2004 Jan 15; 427(6971): 247-52. [PubMed]

Genome

  1. Matsuzaki M, Misumi O, Shin-I T, Maruyama S, Takahara M, Miyagishima SY, Mori T, Nishida K, Yagisawa F, Nishida K, Yoshida Y, Nishimura Y, Nakao S, Kobayashi T, Momoyama Y, Higashiyama T, Minoda A, Sano M, Nomoto H, Oishi K, Hayashi H, Ohta F, Nishizaka S, Haga S, Miura S, Morishita T, Kabeya Y, Terasawa K, Suzuki Y, Ishii Y, Asakawa S, Takano H, Ohta N, Kuroiwa H, Tanaka K, Shimizu N, Sugano S, Sato N, Nozaki H, Ogasawara N, Kohara Y, Kuroiwa T. Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D. Nature. 2004 Apr 8;428(6983):653-7. [PubMed]
  2. Abrahamsen MS, Templeton TJ, Enomoto S, Abrahante JE, Zhu G, Lancto CA, Deng M, Liu C, Widmer G, Tzipori S, Buck GA, Xu P, Bankier AT, Dear PH, Konfortov BA, Spriggs HF, Iyer L, Anantharaman V, Aravind L, Kapur V. Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science. 2004 Apr 16;304(5669):441-5. [PubMed] [Supporting Online Material]  
  3. Gajer P, Schatz M, Salzberg SL. Automated correction of genome sequence errors. Nucleic Acids Res. 2004 Jan 26;32(2):562-569. [PubMed]
  4. Oliver B, Leblanc B. How many genes in a genome? Genome Biol. 2003;5(1):204. [PubMed]

Homo Sapiens/ Human

  1. Bejerano G, Pheasant M, Makunin I, Stephen S, Kent WJ, Mattick JS, Haussler D. Ultraconserved elements in the human genome. Science. 2004 May 28;304(5675):1321-5. [PubMed]
  2. Schmutz J, Wheeler J, Grimwood J, Dickson M, Yang J, Caoile C, Bajorek E, Black S, Chan YM, Denys M, Escobar J, Flowers D, Fotopulos D, Garcia C, Gomez M, Gonzales E, Haydu L, Lopez F, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salazar A, Tsai M, Myers RM. Quality assessment of the human genome sequence. Nature. 2004 May 27;429(6990):365-8. [PubMed]
  3. Humphray SJ, et al., DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [PubMed]
  4. Deloukas P. et al., The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed]
  5. Eichler EE, Clark RA, She X. AN ASSESSMENT OF THE SEQUENCE GAPS: UNFINISHED BUSINESS IN A FINISHED HUMAN GENOME. Nat Rev Genet. 2004 May;5(5):345-54. [PubMed]
  6. Dunham A., et al., The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [PubMed]
  7. Grimwood J. et al., The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed]
  8. Istrail S, Sutton GG, Florea L, Halpern AL, Mobarry CM, Lippert R, Walenz B, Shatkay H, Dew I, Miller JR, Flanigan MJ, Edwards NJ, Bolanos R, Fasulo D, Halldorsson BV, Hannenhalli S, Turner R, Yooseph S, Lu F, Nusskern DR, Shue BC, Zheng XH, Zhong F, Delcher AL, Huson DH, Kravitz SA, Mouchard L, Reinert K, Remington KA, Clark AG, Waterman MS, Eichler EE, Adams MD, Hunkapiller MW, Myers EW, Venter JC. Whole-genome shotgun assembly and comparison of human genome assemblies. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1916-21. [PubMed]
  9. Trinklein ND, Aldred SF, Hartman SJ, Schroeder DI, Otillar RP, Myers RM. An abundance of bidirectional promoters in the human genome. Genome Res. 2004 Jan;14(1):62-6. [PubMed]
  10. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto JI, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-45. [PubMed][web supplement]

Mus Musculus/Mouse

  1. Bailey JA, Church DM, Ventura M, Rocchi M, Eichler EE. Analysis of segmental duplications and genome assembly in the mouse. Genome Res. 2004 May;14(5):789-801. [PubMed]

Rattus norvegicus/Rat

  1. Lindblad-Toh K. Genome sequencing: three's company. Nature. 2004 Apr 1;428(6982):475-6.[PubMed]
  2. Rat Genome Sequencing Project Consortium. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004 Apr 1;428(6982):493-521.  [PubMed]
  3. Rat Genome Special Issue. Genome Research 2004 Apr.

Rhodopseudomonas palustris

  1. Wall JD. Rain or shine-a phototroph that delivers. Nat Biotechnol. 2004 Jan;22(1):40-1.[PubMed]
  2. Larimer FW, Chain P, Hauser L, Lamerdin J, Malfatti S, Do L, Land ML, Pelletier DA, Beatty JT, Lang AS, Tabita FR, Gibson JL, Hanson TE, Bobst C, Torres JL, Peres C, Harrison FH, Gibson J, Harwood CS. Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris. Nat Biotechnol. 2004 Jan;22(1):55-61. [PubMed]

Comparative Genomics

  1. Boffelli D, Nobrega MA, Rubin EM. Comparative genomics at the vertebrate extremes. Nat Rev Genet. 2004 Jun;5(6):456-65. [PubMed]
  2. Weissenbach J. Genome sequencing: differences with the relatives. Nature. 2004 May 27;429(6990):353-5. [PubMed]
  3. Watanabe H, et al., DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature. 2004 May 27;429(6990):382-8. [PubMed]
  4. Paterson AH, Bowers JE, Chapman BA. Ancient polyploidization predating divergence of the cereals, and its consequences for comparative genomics. Proc Natl Acad Sci U S A. 2004 May 25;. [Epub ahead of print] [PubMed]
  5. Li JB, Gerdes JM, Haycraft CJ, Fan Y, Teslovich TM, May-Simera H, Li H, Blacque OE, Li L, Leitch CC, Lewis RA, Green JS, Parfrey PS, Leroux MR, Davidson WS, Beales PL, Guay-Woodford LM, Yoder BK, Stormo GD, Katsanis N, Dutcher SK. Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene. Cell. 2004 May 14;117(4):541-52. [PubMed]
  6. Grad YH, Roth FP, Halfon MS, Church GM. Prediction of similarly-acting cis-regulatory modules by subsequence profiling and comparative genomics in D. melanogaster and D. pseudoobscura. Bioinformatics. 2004 May 14;. [Epub ahead of print] [PubMed]
  7. Castillo-Davis CI, Kondrashov FA, Hartl DL, Kulathinal RJ. The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint. Genome Res. 2004 May;14(5):802-11. [PubMed]
  8. Naruse K, Tanaka M, Mita K, Shima A, Postlethwait J, Mitani H. A medaka gene map: the trace of ancestral vertebrate proto-chromosomes revealed by comparative gene mapping. Genome Res. 2004 May;14(5):820-8. [PubMed]
  9. Dermitzakis ET, Kirkness E, Schwarz S, Birney E, Reymond A, Antonarakis SE. Comparison of human chromosome 21 conserved nongenic sequences (CNGs) with the mouse and dog genomes shows that their selective constraint is independent of their genic environment. Genome Res. 2004 May;14(5):852-9. [PubMed]
  10. Yazaki J, Shimatani Z, Hashimoto A, Nagata Y, Fujii F, Kojima K, Suzuki K, Taya T, Tonouchi M, Nelson C, Nakagawa A, Otomo Y, Murakami K, Matsubara K, Kawai J, Carninci P, Hayashizaki Y, Kikuchi S. Transcriptional profiling of genes responsive to abscisic acid and gibberellin in rice: phenotyping and comparative analysis between rice and Arabidopsis. Physiol Genomics. 2004 Apr 13;17(2):87-100. [PubMed]
  11. Pushker R, Mira A, Rodriguez-Valera F. Comparative genomics of gene-family size in closely related bacteria. Genome Biol. 2004;5(4):R27.[PubMed]
  12. Gilligan P, Venkatesh B. Opinion piece: Application of comparative genomics to the analysis of vertebrate regulatory elements. Brief Funct Genomic Proteomic. 2004 Apr;3(1):7-11. [PubMed]
  13. Castelli V, Aury JM, Jaillon O, Wincker P, Clepet C, Menard M, Cruaud C, Quetier F, Scarpelli C, Schachter V, Temple G, Caboche M, Weissenbach J, Salanoubat M. Whole genome sequence comparisons and "full-length" cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation. Genome Res. 2004 Mar;14(3):406-13. [PubMed]
  14. Wang Z, Fan H, Yang HH, Hu Y, Buetow KH, Lee MP. Comparative sequence analysis of imprinted genes between human and mouse to reveal imprinting signatures. Genomics. 2004 Mar;83(3):395-401. [PubMed]
  15. Ye Y, Godzik A. Comparative analysis of protein domain organization. Genome Res. 2004 Mar;14(3):343-53. [PubMed]
  16. Liu Y, Liu XS, Wei L, Altman RB, Batzoglou S. Eukaryotic regulatory element conservation analysis and identification using comparative genomics. Genome Res. 2004 Mar;14(3):451-8. [PubMed]
  17. Mitreva M, McCarter JP, Martin J, Dante M, Wylie T, Chiapelli B, Pape D, Clifton SW, Nutman TB, Waterston RH. Comparative genomics of gene expression in the parasitic and free-living nematodes Strongyloides stercoralis and Caenorhabditis elegans. Genome Res. 2004 Feb;14(2):209-20. [PubMed]
  18. Lee EJ, Raudsepp T, Kata SR, Adelson D, Womack JE, Skow LC, Chowdhary BP. A 1.4-Mb interval RH map of horse chromosome 17 provides detailed comparison with human and mouse homologues. Genomics. 2004 Feb;83(2):203-15. [PubMed]
  19. Zhang Z. et al., Comparative analysis of processed pseudogenes in the mouse and human genomes. Trends Genet; 2004 Feb [PubMed]
  20. Zhang Z, Carriero N, Gerstein M. Comparative analysis of processed pseudogenes in the mouse and human genomes. Trends Genet. 2004 Feb;20(2):62-7. [PubMed]
  21. La Rota M, Sorrells ME. Comparative DNA sequence analysis of mapped wheat ESTs reveals the complexity of genome relationships between rice and wheat. Funct Integr Genomics. 2004 Jan 22 [Epub ahead of print][PubMed]
  22. Ge H, Chuang YY, Zhao S, Tong M, Tsai MH, Temenak JJ, Richards AL, Ching WM. Comparative Genomics of Rickettsia prowazekii Madrid E and Breinl Strains. J Bacteriol. 2004 Jan 15;186(2):556-565. [PubMed]
  23. Goo YA, Roach J, Glusman G, Baliga NS, Deutsch K, Pan M, Kennedy S, DasSarma S, Ng WV, Hood L. Low-pass sequencing for microbial comparative genomics. BMC Genomics. 2004 Jan 12 [Epub ahead of print] [PubMed]
  24. Elson JL, Turnbull DM, Howell N. Comparative Genomics and the Evolution of Human Mitochondrial DNA: Assessing the Effects of Selection. Am J Hum Genet. 2004 Jan 7 [Epub ahead of print] [PubMed]
  25. Avison MB. Comparative genomics: digging for data. Methods Mol Biol. 2004;266:47-70. [PubMed]

Population Genomics/Evolutionary Genomics

  1. Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J. Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9786-91. [PubMed]
  2. Marchini J, Cardon LR, Phillips MS, Donnelly P. The effects of human population structure on large genetic association studies. Nat Genet. 2004 May;36(5):512-7. [PubMed]
  3. Kazazian HH Jr. Mobile elements: drivers of genome evolution. Science. 2004 Mar 12;303(5664):1626-32. [PubMed]
  4. Snel B, Huynen MA. Quantifying modularity in the evolution of biomolecular systems. Genome Res. 2004 Mar;14(3):391-7. [PubMed]
  5. McAdams HH, Srinivasan B, Arkin AP. The evolution of genetic regulatory systems in bacteria. Nat Rev Genet. 2004 Mar;5(3):169-178. [PubMed]
  6. Baudouin-Cornu P, Schuerer K, Marliere P, Thomas D. Intimate Evolution of Proteins: PROTEOME ATOMIC CONTENT CORRELATES WITH GENOME BASE COMPOSITION. J Biol Chem. 2004 Feb 13;279(7):5421-8. [PubMed]
  7. Schaffner SF. The X chromosome in population genetics. Nat Rev Genet. 2004 Jan;5(1):43-51. [PubMed]

Network/pathway reconstruction and analysis

  1. Segrè D. The regulatory software of cellular metabolism. Trends Biotechnol. 2004 Jun;22(6):261-5. [PubMed]
  2. Zaslaver A, Mayo AE, Rosenberg R, Bashkin P, Sberro H, Tsalyuk M, Surette MG, Alon U. Just-in-time transcription program in metabolic pathways. Nat Genet. 2004 May;36(5):486-91. [PubMed]
  3. Basu S, Mehreja R, Thiberge S, Chen MT, Weiss R. Spatiotemporal control of gene expression with pulse-generating networks. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6355-60. [PubMed]
  4. Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M. Systematic Interactome Mapping and Genetic Perturbation Analysis of a C. elegans TGF-beta Signaling Network. Mol Cell. 2004 Feb 27;13(4):469-82. [PubMed]
  5. Tong AH, Lesage G, Bader GD, Ding H, Xu H, Xin X, Young J, Berriz GF, Brost RL, Chang M, Chen Y, Cheng X, Chua G, Friesen H, Goldberg DS, Haynes J, Humphries C, He G, Hussein S, Ke L, Krogan N, Li Z, Levinson JN, Lu H, Menard P, Munyana C, Parsons AB, Ryan O, Tonikian R, Roberts T, Sdicu AM, Shapiro J, Sheikh B, Suter B, Wong SL, Zhang LV, Zhu H, Burd CG, Munro S, Sander C, Rine J, Greenblatt J, Peter M, Bretscher A, Bell G, Roth FP, Brown GW, Andrews B, Bussey H, Boone C. Global mapping of the yeast genetic interaction network. Science. 2004 Feb 6;303(5659):808-13. [PubMed][Supporting Online Material]  
  6. Crawford GE, Holt IE, Mullikin JC, Tai D, National Institutes Of Health Intramural Sequencing Center, Blakesley R, Bouffard G, Young A, Masiello C, Green ED, Wolfsberg TG, Collins FS. Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):992-7. [PubMed]
  7. Pritsker M, Liu YC, Beer MA, Tavazoie S. Whole-genome discovery of transcription factor binding sites by network-level conservation. Genome Res. 2004 Jan;14(1):99-108. [PubMed]

Metabolomics

  1. Segrè D. The regulatory software of cellular metabolism. Trends Biotechnol. 2004 Jun;22(6):261-5. [PubMed]
  2. Kell DB. Metabolomics and systems biology: making sense of the soup. Curr Opin Microbiol. 2004 Jun;7(3):296-307. [PubMed]
  3. Schwender J, Ohlrogge J, Shachar-Hill Y. Understanding flux in plant metabolic networks. Curr Opin Plant Biol. 2004 Jun;7(3):309-17. [PubMed]
  4. Wiback SJ, Mahadevan R, Palsson BO. Using metabolic flux data to further constrain the metabolic solution space and predict internal flux patterns: the Escherichia coli spectrum. Biotechnol Bioeng. 2004 May 5;86(3):317-31. [PubMed]
  5. Cakir T, Kirdar B, Ulgen KO. Metabolic pathway analysis of yeast strengthens the bridge between transcriptomics and metabolic networks. Biotechnol Bioeng. 2004 May 5;86(3):251-60. [PubMed]
  6. Zaslaver A, Mayo AE, Rosenberg R, Bashkin P, Sberro H, Tsalyuk M, Surette MG, Alon U. Just-in-time transcription program in metabolic pathways. Nat Genet. 2004 May;36(5):486-91. [PubMed]
  7. Goodacre R, Vaidyanathan S, Dunn WB, Harrigan GG, Kell DB. Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol. 2004 May;22(5):245-52. [PubMed]
  8. Lee K, Hwang D, Yokoyama T, Stephanopoulos G, Stephanopoulos GN, Yarmush ML. Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. Bioinformatics 2004 Apr 12; 20:959-969 [PubMed]
  9. Brown SC, Kruppa G, Dasseux JL. Metabolomics applications of FT-ICR mass spectrometry. Mass Spectrom Rev. 2004 Mar 30 [Epub ahead of print] [PubMed]
  10. Voit EO, Almeida J. Decoupling dynamical systems for pathway identification from metabolic profiles. Bioinformatics. 2004 Feb 26 [Epub ahead of print] [PubMed]
  11. Almaas E, Kovacs B, Vicsek T, Oltvai ZN, Barabasi AL. Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature. 2004 Feb 26;427(6977):839-43.  [PubMed]
  12. Patil KR. et al., Use of genome-scale microbial models for metabolic engineering. Curr Opin Biotechnol. 2004 Feb; [PubMed]
  13. Sauer U. High-throughput phenomics: experimental methods for mapping fluxomes.  Curr Opin Biotechnol. 2004 Feb; [PubMed]
  14. Hellerstein MK. New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping. Metab Eng. 2004 Jan; 6(1): 85-100. [PubMed]

Pharmacogenomics

  1. Evans WE, Relling MV. Moving towards individualized medicine with pharmacogenomics. Nature. 2004 May 27;429(6990):464-8. [PubMed]
  2. Strausberg RL, Simpson AJ, Old LJ, Riggins GJ. Oncogenomics and the development of new cancer therapies. Nature. 2004 May 27;429(6990):469-74. [PubMed]
  3. Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Richter B, Israel E, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. Corticosteroid Pharmacogenetics: Association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004 May 5;. [Epub ahead of print] [PubMed]
  4. Bredel M, Jacoby E. Chemogenomics: an emerging strategy for rapid target and drug discovery. Nat Rev Genet. 2004 Apr;5(4):262-75. [PubMed]
  5. Pirazzoli A, Recchia G. Pharmacogenetics and pharmacogenomics: are they still promising? Pharmacol Res. 2004 Apr;49(4):357-61.  [PubMed]
  6. Cattaneo D, Perico N, Remuzzi G. From pharmacokinetics to pharmacogenomics: a new approach to tailor immunosuppressive therapy. Am J Transplant. 2004 Mar;4(3):299-310. [PubMed]
  7. McLeod HL. Drug pathways: moving beyond single gene pharmacogenetics. Pharmacogenomics. 2004 Mar;5(2):139-41. [PubMed]
  8. Albers LJ, Ozdemir V. Pharmacogenomic-guided rational therapeutic drug monitoring: conceptual framework and application platforms for atypical antipsychotics. Curr Med Chem. 2004 Feb;11(3):297-312. [PubMed]
  9. Hampton T. FDA seeks genome-based drug data. JAMA. 2004 Jan 7; 291(1): 32-3. [PubMed]
  10. Capecchi B, Serruto D, Adu-Bobie J, Rappuoli R, Pizza M. The genome revolution in vaccine research. Curr Issues Mol Biol. 2004 Jan;6(1):17-27. [PubMed]
  11. Tempfer CB, Schneeberger C, Huber JC. Applications of polymorphisms and pharmacogenomics in obstetrics and gynecology. Pharmacogenomics. 2004 Jan;5(1):57-65. [PubMed]
  12. Lymberis SC, Parhar PK, Katsoulakis E, Formenti SC. Pharmacogenomics and breast cancer. Pharmacogenomics. 2004 Jan;5(1):31-55. [PubMed]
  13. Freeman BD, McLeod HL. Challenges of implementing pharmacogenetics in the critical care environment. Nat Rev Drug Discov. 2004 Jan;3(1):88-93. [PubMed]
  14. Fizames C, Munos S, Cazettes C, Nacry P, Boucherez J, Gaymard F, Piquemal D, Delorme V, Commes T, Doumas P, Cooke R, Marti J, Sentenac H, Gojon A. The Arabidopsis root transcriptome by serial analysis of gene expression. Gene identification using the genome sequence. Plant Physiol. 2004 Jan; 134(1): 67-80. [PubMed]

Toxicogenomics

  1. Pennie W, Pettit SD, Lord PG. Toxicogenomics in risk assessment: an overview of an HESI collaborative research program. Environ Health Perspect. 2004 Mar;112(4):417-9. [PubMed]

System Biology

  1. Kell DB. Metabolomics and systems biology: making sense of the soup. Curr Opin Microbiol. 2004 Jun;7(3):296-307. [PubMed]
  2. Yates JR 3rd. Mass spectrometry as an emerging tool for systems biology. Biotechniques. 2004 Jun;36(6):917-9. [PubMed]
  3. Ideker T. Systems biology 101—what you need to know. Nat Biotechnol. 2004 Apr;22(4):473-5.[PubMed]
  4. Weston AD, Hood L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J Proteome Res. 2004 Mar-Apr;3(2):179-96. [PubMed]
  5. Hammer GL, Sinclair TR, Chapman SC, Van Oosterom E. On systems thinking, systems biology, and the in silico plant. Plant Physiol. 2004 Mar;134(3):909-11. [PubMed]
  6. Cowley AW Jr. The elusive field of systems biology. Physiol Genomics. 2004 Feb 13;16(3):285-6. [PubMed]
  7. Huang S. Back to the biology in systems biology: what can we learn from biomolecular networks? Brief Funct Genomic Proteomic. 2004 Feb;2(4):279-97. [PubMed]
  8. Stevens CF. Systems biology versus molecular biology. Curr Biol. 2004 Jan 20; 14(2): R51-2. [PubMed]
  9. Zhu H, Huang S, Dhar P. The next step in systems biology: simulating the temporospatial dynamics of molecular network. Bioessays. 2004 Jan;26(1):68-72. [PubMed]
  10. Wall ME, Hlavacek WS, Savageau MA. Design of gene circuits: lessons from bacteria. Nat Rev Genet. 2004 Jan;5(1):34-42. [PubMed]
  11. You L. Toward computational systems biology. Cell Biochem Biophys. 2004;40(2):167-84. [PubMed]

Database

  1. Jones A, Hunt E, Wastling J, Pizarro A, Stoeckert CJ Jr. An object model and database for functional genomics. Bioinformatics. 2004 May 14;. [Epub ahead of print][PubMed]

Applications

  1. <>Kunkel EJ, Dea M, Ebens A, Hytopoulos E, Melrose J, Nguyen D, Ota KS, Plavec I, Wang Y, Watson SR, Butcher EC, Berg EL. An integrative biology approach for analysis of drug action in models of human vascular inflammation. FASEB J. 2004 Jun 18;. [Epub ahead of print] [PubMed]
  2. <>Kalir S, Alon U. Using a quantitative blueprint to reprogram the dynamics of the flagella gene network. Cell. 2004 Jun 11;117(6):713-20. [PubMed]
  3. Wollscheid B, Watts JD, Aebersold R. Proteomics/genomics and signaling in lymphocytes. Curr Opin Immunol. 2004 Jun;16(3):337-44. [PubMed]
  4. Pompeia C, Hurle B, Belyantseva IA, Noben-Trauth K, Beisel K, Gao J, Buchoff P, Wistow G, Kachar B. Gene expression profile of the mouse organ of corti at the onset of hearing. Genomics. 2004 Jun;83(6):1000-11. [PubMed]
  5. Gong W, Shen YP, Ma LG, Pan Y, Du YL, Wang DH, Yang JY, Hu LD, Liu XF, Dong CX, Ma L, Chen YH, Yang XY, Gao Y, Zhu D, Tan X, Mu JY, Zhang DB, Liu YL, Dinesh-Kumar SP, Li Y, Wang XP, Gu HY, Qu LJ, Bai SN, Lu YT, Li JY, Zhao JD, Zuo J, Huang H, Deng XW, Zhu YX. Genome-Wide ORFeome Cloning and Analysis of Arabidopsis Transcription Factor Genes. Plant Physiol. 2004 Jun;135(2):773-82. [PubMed]
  6. Thomas JD, Lee T, Suh NP. A function-based framework for understanding biological systems. Annu Rev Biophys Biomol Struct. 2004 Jun;33:75-93. [PubMed]
  7. Kim NS, Hahn Y, Oh JH, Lee JY, Oh KJ, Kim JM, Park HS, Kim S, Song KS, Rho SM, Yoo HS, Kim YS. Gene cataloging and expression profiling in human gastric cancer cells by expressed sequence tags. Genomics. 2004 Jun;83(6):1024-45. [PubMed]
  8. Bell J. Predicting disease using genomics. Nature. 2004 May 27;429(6990):453-6. [PubMed]
  9. Boguski MS, Jones AR. Neurogenomics: at the intersection of neurobiology and genome sciences. Nat Neurosci. 2004 May;7(5):429-33. [PubMed]
  10. Choudhary J, Grant SG. Proteomics in postgenomic neuroscience: the end of the beginning. Nat Neurosci. 2004 May;7(5):440-5. [PubMed][Supplementary Information]
  11. Buzsaki G. Large-scale recording of neuronal ensembles. Nat Neurosci. 2004 May;7(5):446-51. [PubMed]
  12. Tecott LH, Nestler EJ. Neurobehavioral assessment in the information age. Nat Neurosci. 2004 May;7(5):462-6. [PubMed]
  13. Nollen EA, Garcia SM, Van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6403-8. [PubMed]
  14. te Pas MF, Claes F. Functional genomics and proteomics for infectious diseases in the post-genomics era. Lancet. 2004 Apr 24;363(9418):1337. [PubMed]
  15. Laffin JJ, Scheetz TE, Bonaldo Mde F, Reiter RS, Chang S, Eyestone M, Abdulkawy H, Brown B, Roberts C, Tack D, Kucaba T, Lin JJ, Sheffield VC, Casavant TL, Soares MB. A comprehensive nonredundant expressed sequence tag collection for the developing Rattus norvegicus heart. Physiol Genomics. 2004 Apr 13;17(2):245-52. [PubMed]
  16. Seo TS, Bai X, Ruparel H, Li Z, Turro NJ, Ju J. Photocleavable fluorescent nucleotides for DNA sequencing on a chip constructed by site-specific coupling chemistry. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5488-93. [PubMed]
  17. Tsolaki AG, Hirsh AE, DeRiemer K, Enciso JA, Wong MZ, Hannan M, Goguet De La Salmoniere YO, Aman K, Kato-Maeda M, Small PM. Functional and evolutionary genomics of Mycobacterium tuberculosis: Insights from genomic deletions in 100 strains. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4865-70. [PubMed]
  18. Falkowski PG, de Vargas C. Shotgun Sequencing in the Sea: A Blast from the Past? Science. 2004 Apr 2;304(5667):58-60. [PubMed]
  19. Venter JC, Remington K, Heidelberg JF, Halpern AL, Rusch D, Eisen JA, Wu D, Paulsen I, Nelson KE, Nelson W, Fouts DE, Levy S, Knap AH, Lomas MW, Nealson K, White O, Peterson J, Hoffman J, Parsons R, Baden-Tillson H, Pfannkoch C, Rogers YH, Smith HO. Environmental Genome Shotgun Sequencing of the Sargasso Sea. Science. 2004 Apr 2;304(5667):66-74. [PubMed]
  20. Weiss A, Delproposto J, Giroux CN. High-throughput phenotypic profiling of gene-environment interactions by quantitative growth curve analysis in Saccharomyces cerevisiae. Anal Biochem. 2004 Apr 1;327(1):23-34. [PubMed]
  21. Andersson A, Keskitalo J, Sjodin A, Bhalerao R, Sterky F, Wissel K, Tandre K, Aspeborg H, Moyle R, Ohmiya Y, Bhalerao R, Brunner A, Gustafsson P, Karlsson J, Lundeberg J, Nilsson O, Sandberg G, Strauss S, Sundberg B, Uhlen M, Jansson S, Nilsson P. A transcriptional timetable of autumn senescence. Genome Biol. 2004;5(4):R24. [PubMed]
  22. Astin J, Merry A, Rajan J, Kuwabara PE. Caenorhabditis elegans functional genomics: Omic resonance. Brief Funct Genomic Proteomic. 2004 Apr;3(1):26-34. [PubMed]
  23. Li KC, Yuan S. A functional genomic study on NCI's anticancer drug screen. Pharmacogenomics J. 2004 Mar 2 [Epub ahead of print] [PubMed]
  24. Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR. Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat Genet. 2004 Mar;36(3):257-63.  [PubMed]
  25. Sugimoto A. High-throughput RNAi in Caenorhabditis elegans: genome-wide screens and functional genomics. Differentiation. 2004 Mar;72(2-3):81-91. [PubMed]
  26. Orlandi I, Bettiga M, Alberghina L, Vai M. Transcriptional profiling of ubp10 null mutant reveals subtelomeric gene expression and insurgence of oxidative stress response. J Biol Chem. 2004 Feb 20 [PubMed]
  27. Weeraratna AT, Becker D, Carr KM, Duray PH, Rosenblatt KP, Yang S, Chen Y, Bittner M, Strausberg RL, Riggins GJ, Wagner U, Kallioniemi OP, Trent JM, Morin PJ, Meltzer PS. Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome. Oncogene. 2004 Feb 2 [Epub ahead of print] [PubMed]
  28. Rual J et al., ORFeome projects: gateway between genomics and omics. Curr Opin Chem Biol.  2004 Feb [PubMed]
  29. Seta KA, Millhorn DE. Functional genomics approach to hypoxia signaling. J Appl Physiol. 2004 Feb; 96(2): 765-73. [PubMed]
  30. Nagaki K, Cheng Z, Ouyang S, Talbert PB, Kim M, Jones KM, Henikoff S, Buell CR, Jiang J. Sequencing of a rice centromere uncovers active genes. Nat Genet. 2004 Feb;36(2):138-45. [PubMed]
  31. Griffin JL, Bonney SA, Mann C, Hebbachi AM, Gibbons GF, Nicholson JK, Shoulders CC, Scott J.  An Integrated Reverse Functional Genomic and Metabolic Approach to Understanding Orotic Acid Induced Fatty Liver. Physiol Genomics. 2004 Jan 27 [Epub ahead of print]  [PubMed]
  32. Tijsterman M, May RC, Simmer F, Okihara KL, Plasterk RH. Genes Required for Systemic RNA Interference in Caenorhabditis elegans. Curr Biol. 2004 Jan 20; 14(2): 111-6. [PubMed]
  33. Giaever G, Flaherty P, Kumm J, Proctor M, Nislow C, Jaramillo DF, Chu AM, Jordan MI, Arkin AP, Davis RW. Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3): 793-8. [PubMed][Supporting Information]
  34. Stover PJ. Nutritional genomics. Physiol Genomics. 2004 Jan 15; 16(2): 161-5. [PubMed]
  35. Kaput J, Rodriguez RL. Nutritional genomics: the next frontier in the postgenomic era. Physiol Genomics. 2004 Jan 15; 16(2): 166-77. [PubMed]
  36. McBride MW, Charchar FJ, Graham D, Miller WH, Strahorn P, Carr FJ, Dominiczak AF. Functional genomics in rodent models of hypertension. J Physiol. 2004 Jan 1;554(Pt 1):56-63. [PubMed]
  37. Fraser CM. A genomics-based approach to biodefence preparedness. Nat Rev Genet. 2004 Jan;5(1):23-33. [PubMed]
  38. Carpenter AE, Sabatini DM. Systematic genome-wide screens of gene function. Nat Rev Genet. 2004 Jan;5(1):11-22. [PubMed]
  39. Stockwell BR. The biological magic behind the bullets. Nat Biotechnol. 2004 Jan;22(1):37-38. [PubMed]

Single Nucleotide Polymorphisms (SNPs) & haplotyping (typing, validation and mapping)

  1. Stewart CA, Horton R, Allcock RJ, Ashurst JL, Atrazhev AM, Coggill P, Dunham I, Forbes S, Halls K, Howson JM, Humphray SJ, Hunt S, Mungall AJ, Osoegawa K, Palmer S, Roberts AN, Rogers J, Sims S, Wang Y, Wilming LG, Elliott JF, De Jong PJ, Sawcer S, Todd JA, Trowsdale J, Beck S. Complete MHC haplotype sequencing for common disease gene mapping. Genome Res. 2004 Jun;14(6):1176-87.  [PubMed]
  2. Clifford RJ, Edmonson MN, Nguyen C, Buetow KH. Large-scale analysis of non-synonymous coding region single nucleotide polymorphisms. Bioinformatics. 2004 May 1;20(7):1006-14. [PubMed]
  3. Zhang K, Qin ZS, Liu JS, Chen T, Waterman MS, Sun F. Haplotype block partitioning and tag SNP selection using genotype data and their applications to association studies. Genome Res. 2004 May;14(5):908-16. [PubMed]
  4. Wu SJ, Chiang FT, Chen WJ, Liu PH, Hsu KL, Hwang JJ, Lai LP, Lin JL, Tseng CD, Tseng YZ. Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. Physiol Genomics. 2004 Apr 13;17(2):79-86. [PubMed]
  5. Kang H, Qin ZS, Niu T, Liu JS. Incorporating Genotyping Uncertainty in Haplotype Inference for Single-Nucleotide Polymorphisms. Am J Hum Genet. 2004 Mar;74(3):495-510. [PubMed]
  6. Schwarz G, Baumler S, Block A, Felsenstein FG, Wenzel G. Determination of detection and quantification limits for SNP allele frequency estimation in DNA pools using real time PCR. Nucleic Acids Res. 2004 Feb 11;32(3):E24. [PubMed]
  7. Zimdahl H, Nyakatura G, Brandt P, Schulz H, Hummel O, Fartmann B, Brett D, Droege M, Monti J, Lee YA, Sun Y, Zhao S, Winter EE, Ponting CP, Chen Y, Kasprzyk A, Birney E, Ganten D, Hubner N. A SNP map of the rat genome generated from cDNA sequences. Science. 2004 Feb 6;303(5659):807. [PubMed] [Supporting Online Material]  
  8. Schulze TG, Zhang K, Chen YS, Akula N, Sun F, McMahon FJ. Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome. Hum Mol Genet. 2004 Feb 1; 13(3): 335-42. [PubMed][Supplementary Material]
  9. Rice MC, Heckman BM, Liu Y, Kmiec EB. Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides. Genome Res. 2004 Jan; 14(1): 116-25. [PubMed]
  10. Stanssens P, Zabeau M, Meersseman G, Remes G, Gansemans Y, Storm N, Hartmer R, Honisch C, Rodi CP, Bocker S, van den Boom D. High-throughput MALDI-TOF discovery of genomic sequence polymorphisms. Genome Res. 2004 Jan; 14(1): 126-33. [PubMed]
  11. Smylie KJ, Cantor CR, Denissenko MF. Analysis of sequence variations in several human genes using phosphoramidite bond DNA fragmentation and chip-based MALDI-TOF. Genome Res. 2004 Jan; 14(1): 134-41. [PubMed][Supplemental Research Data]
  12. Lavebratt C, Sengul S, Jansson M, Schalling M. Pyrosequencing-based SNP allele frequency estimation in DNA pools. Hum Mutat. 2004 Jan;23(1):92-7. [PubMed]
  13. Eronen L, Geerts F, Toivonen H. A Markov chain approach to reconstruction of long haplotypes. Pac Symp Biocomput. 2004;:104-15. [PubMed]
  14. Zhu X, Zhang S, Kan D, Cooper R. Haplotype block definition and its application. Pac Symp Biocomput. 2004;:152-63. [PubMed]

Techniques & Tools

  1. Skarnes WC, Von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J. A public gene trap resource for mouse functional genomics. Nat Genet. 2004 Jun;36(6):543-4. [PubMed]
  2. Manly KF, Nettleton D, Hwang JT. Genomics, prior probability, and statistical tests of multiple hypotheses. Genome Res. 2004 Jun;14(6):997-1001. [PubMed]
  3. Bell J. Predicting disease using genomics. Nature. 2004 May 27;429(6990):453-6. [PubMed]
  4. Henikoff S, Till BJ, Comai L. TILLING. Traditional Mutagenesis Meets Functional Genomics. Plant Physiol. 2004 May 21;. [Epub ahead of print][PubMed]
  5. Shendure J, Mitra RD, Varma C, Church GM. ADVANCED SEQUENCING TECHNOLOGIES: METHODS AND GOALS. Nat Rev Genet. 2004 May;5(5):335-44. [PubMed]
  6. Barker DL, Hansen MS, Faruqi AF, Giannola D, Irsula OR, Lasken RS, Latterich M, Makarov V, Oliphant A, Pinter JH, Shen R, Sleptsova I, Ziehler W, Lai E. Two methods of whole-genome amplification enable accurate genotyping across a 2320-SNP linkage panel. Genome Res. 2004 May;14(5):901-7. [PubMed]
  7. Mikkilineni V, Mitra RD, Merritt J, DiTonno JR, Church GM, Ogunnaike B, Edwards JS. Digital quantitative measurements of gene expression. Biotechnol Bioeng. 2004 Apr 20;86(2):117-24. [PubMed]
  8. Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ. A resource for large-scale RNA-interference-based screens in mammals. Nature. 2004 Mar 25;428(6981):427-31. [PubMed]
  9. Fraser A. RNA interference: human genes hit the big screen. Nature. 2004 Mar 25;428(6981):375-8. [PubMed]
  10. Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR. Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat Genet. 2004 Mar;36(3):257-63.  [PubMed]
  11. Grimm S. The art and design of genetic screens: mammalian culture cells. Nat Rev Genet. 2004 Mar;5(3):179-189. [PubMed]
  12. Thibault ST, Singer MA, Miyazaki WY, Milash B, Dompe NA, Singh CM, Buchholz R, Demsky M, Fawcett R, Francis-Lang HL, Ryner L, Cheung LM, Chong A, Erickson C, Fisher WW, Greer K, Hartouni SR, Howie E, Jakkula L, Joo D, Killpack K, Laufer A, Mazzotta J, Smith RD, Stevens LM, Stuber C, Tan LR, Ventura R, Woo A, Zakrajsek I, Zhao L, Chen F, Swimmer C, Kopczynski C, Duyk G, Winberg ML, Margolis J. A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet. 2004 Mar;36(3):283-7.[PubMed]
  13. Parks AL, Cook KR, Belvin M, Dompe NA, Fawcett R, Huppert K, Tan LR, Winter CG, Bogart KP, Deal JE, Deal-Herr ME, Grant D, Marcinko M, Miyazaki WY, Robertson S, Shaw KJ, Tabios M, Vysotskaia V, Zhao L, Andrade RS, Edgar KA, Howie E, Killpack K, Milash B, Norton A, Thao D, Whittaker K, Winner MA, Friedman L, Margolis J, Singer MA, Kopczynski C, Curtis D, Kaufman TC, Plowman GD, Duyk G, Francis-Lang HL. Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome. Nat Genet. 2004 Mar;36(3):288-92. [PubMed]
  14. Brown AC, Kai K, May ME, Brown DC, Roopenian DC. ExQuest, a novel method for displaying quantitative gene expression from ESTs. Genomics. 2004 Mar;83(3):528-39.  [PubMed]
  15. Mitsopoulos G. et al., Tagged library approach to chemical genomics and proteomics. Curr Opin Chem Biol.  2004 Feb [PubMed]
  16. Stemple DL. Innovation: TILLING - a high-throughput harvest for functional genomics. Nat Rev Genet. 2004 Feb;5(2):145-150. [PubMed]
  17. Kurtz S, Phillippy A, Delcher AL, Smoot M, Shumway M, Antonescu C, Salzberg SL. Versatile and open software for comparing large genomes. Genome Biol. 2004;5(2):R12. [PubMed]
  18. Dhar P, Meng TC, Somani S, Ye L, Sairam A, Chitre M, Hao Z, Sakharkar K. Cellware--a multi-algorithmic software for computational systems biology. Bioinformatics. 2004 Feb 10 [Epub ahead of print] [PubMed]
  19. Ruan Y, Le Ber P, Hui Ng H, Liu ET. Interrogating the transcriptome. Trends Biotechnol. 2004 Jan;22(1):23-30. [PubMed]

Ethical, Legal and Social issues

  1. The International HapMap Consortium. Opinion: Integrating ethics and science in the International HapMap Project. Nat Rev Genet. 2004 Jun;5(6):467-75. [PubMed]
  2. Turner L. Science, politics and the President's Council on Bioethics. Nat Biotechnol. 2004 May;22(5):509-10. [PubMed]
  3. Blackburn E.  Bioethics and the Political Distortion of Biomedical Science. New Engl J Med. 2004 Apr [PubMed]
  4. Sharp RR. et al., SHAPING SCIENCE POLICY IN THE AGE OF GENOMICS. Nat Rev Genet. 2004 Apr [PubMed]
  5. Mordini E. Ethical considerations on pharmacogenomics. Pharmacol Res. 2004 Apr;49(4):375-9. [PubMed]

last updated: 6 Ju1 2004
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